The Effect of an Aquatic Extract of Eucalyptus globulus Leaves on Reducing the Inflammation Parameters Caused by Carrageenan in Male Wistar Rats

Abstract

This research looked at how an aquatic Eucalyptus globulus extract (ECP) affected inflammation and oxidative stress in male rats that were given an experimental form of carrageenan (CRG). The study randomly assigned twenty-four male Wistar rats. In the study, 2 ml of physiological solution was administered to the control group, 0.6 g/kg of ECP BW was given to the ECP group orally, 100 μl of the CRG solution dissolved in 1 milliliter of distilled water was injected intraperitoneally to the CRG group for 30 days, and 0.6 g/kg of BW of ECP was given orally to the C&E group for 15 days after 15 days of 100 μl of the carrageenan solution dissolved in 1 milliliter of distilled water intraperitoneal injection. We sacrificed the rats after 30 days and analyzed the serum samples to measure white blood cell count (WBC), lymphocytes, monocytes, neutrophils, C-reactive protein (CRP), and tumor necrosis factor (TNF). The study found that the CRG and C&E groups had higher levels of WBC, lymphocytes, monocytes, neutrophils, CRP, and TNF than the ECP and control groups. The decrease in inflammation markers CRP and TNF in the serum of E&C group rats demonstrates that ECP's aqueous extract has anti-inflammatory properties. However, further clinical and histological research is necessary to validate its potential as a therapeutic agent.