Abstract
Background and Aims : Recent studies revealed that hypoxia contributes to vascular calcification via the activation of hypoxia-inducible factor 1 (HIF-1) pathway. The alpha-ketoglutarate-dependent prolyl hydroxylase domain enzymes regulate the stability of HIF-1α in response to oxygen availability. As a rate-limiting substrate, alpha-ketoglutarate regulates the activity of prolyl hydroxylases, therefore we addressed the inhibitory effect of alpha-ketoglutarate on vascular smooth muscle cell calcification under hypoxic condition.
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