Abstract

Abstract Lung retention was followed for up to 640 days in groups of rats that had inhaled different amounts of a mixed actinide oxide containing 239Pu and 241Am, and/or fused aluminosilicate particles (FAP) labelled with 57Co. Lung retention of 239Pu in the rats exposed at the lowest level (initial lung deposit 0.1 kBq, total alpha activity) was greater than that of 57Co, the difference being attributed to faster dissolution of the FAP. At the higher levels of the mixed actinide oxide (2 and 9 kBq, total alpha activity), greater retention of the mixed actinide oxide occurred, and at the highest level greater retention of FAP also occurred, these effects being attributable to impaired clearance resulting from alpha radiation induced lung damage.

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