Abstract
Background: Herbal drugs have been used to treat several diseases from liver and neural disorders to diabetes. Our study was aimed to find out the effects of alcoholic ginger extract on testis/body weight and apoptosis of sperm germ cells of chronic diabetic rat. Methods: In this experimental study, sixty male Wistar rats were randomly divided into 5 groups: nontreatment normal (group 1), non-treatment diabetic (group 2), ginger treatment diabetic (group 3), insulin treatment diabetic (group 4) and ginger plus insulin treatment diabetic (group 5). Ginger alcohol extract was injected intraperitoneally at the dose of 200 mg/kg for 6 weeks. TUNEL method was employed to evaluate the germ cells apoptosis. Expression of Bax, Bcl-2, CyclinD1, TRPV1, TLR2 and TLR4 was evaluated using Real-Time PCR technique. Results: Results revealed a significant decrease in the apoptosis index in the group 5 with respect to the group 2 (P<0.05). The expression of BAX, BCL2, TRPV1, TLR2 and TLR4 significantly decreased, while CYC D1 was increased in the group 5 in comparison to group 2. Conclusions: These results suggest ginger has a potentially beneficial role in reducing apoptosis and inflammation in testicular germ cells in chronic diabetic adult rats.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Asian Journal of Biomedical and Pharmaceutical Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
