Abstract

This research presents an investigation on the simultaneous effect of titanium (Ti) and silver (Ag) on structural and biological behaviors of the co-substituted 58S bioactive glass. Structural and morphological characterizations were studied by means of X-ray diffraction (XRD) analysis, Fourier transform infrared spectrum (FTIR), scanning electron microscopy (SEM) as well as Energy-dispersive X-ray Spectroscopy (EDS) analysis. The structural results exhibited that the hydroxyapatite)HA) layer was formed on the T/A-BGs after the 7th day of immersion in simulated body fluid)SBF(solution and increased overtime. Furthermore, the trend of cell proliferation and antibacterial activity were the same and by increasing Ag percentage up to 8 mol.% firstly, mentioned properties increased and then decreased. Hence, T/A-BG containing fixed 5 mol.% Ti and 2 mol. % Ag (TA2 (indicated higher in vitro biological performance compared to other synthesized T/A-BGs and suggested as an optimal specimen for further clinical applications.

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