Abstract
Silver nanoparticles and silver species are frequently used in regenerative medicine due to their bactericidal effect and low toxicity to human cells. Ag species are prone to be converted into other silver species such as silver nanoparticles and AgCl when immersed in simulated body fluid. The aim of this study is to understand the influence of these transformations in the human body, as well as the effect of different oxidative states of Ag on bioactivity, cell viability and antibacterial activity. For this purpose, bioactive glasses with different silver species and content were used, obtaining glasses with Ag2O or Ag3PO4. The presence of Ag+ ions favored the appearance of AgCl crystals on the surface of the samples after their immersion in simulated body fluid. In all cases, Ag nanoparticles were formed due to the high concentration of NaCl in the simulated body fluid, which concentration is close to the human plasma.
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