Abstract
Several hormones are known to influence the spread of dyes in dermal connective tissue. Anterior pituitary extract decreased the spread of Indian ink when injected together with testicular extract (Weinstein, 1940). An inhibition of the spread of the dye was also found after treatment with posterior pituitary hormone (Favilli, 1939). In these cases it is impossible to exclude interference of hormones from the other pituitary lobe owing to the difficulty of isolating anterior and posterior pituitary hormones from each other. Other hormones reported to influence the spread might have acted indirectly upon the pituitary. Thus, adrenaline (Favilli, 1939, Homburger, 1944) and oestrogens (Sprunt, McDearman & Raper, 1938, Sprunt & McDearman, 1939, 1940) inhibited the spread and also stimulated the output of adrenocorticotrophic hormone (Vogt, 1944, Christensen, 1944, Long & Fry, 1945, Selye, 1946, Lurie, 1950). In some recent papers (Opsahl, 1949 a, b, c, Opsahl, White & Duran-Reynals, 1950) adrenocortical
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