Abstract
The effect of a vaginal gel with hop cones phytoestrogens on the hormonal state and morphostructure of the reproductive organs in spayed rats
Highlights
IntroductionThe data obtained show prospects for development of vaginal drug dosage forms with the hop cones extract for treating urogenital disfunctions in the climacteric syndrome
National University of Pharmacy Institute for Continuing Education of Pharmacy Professionals at the National University of Pharmacy*
The animals were divided into five groups: intact animals (IC); sham-operated female rats (SOF); control pathology (CP); spayed rats treated with the vaginal gel with hop cones dense extract (HCDE); spay animals treated with the reference drug – “Ovestin” vaginal suppositories, the active ingredient was estriol (E)
Summary
The data obtained show prospects for development of vaginal drug dosage forms with the hop cones extract for treating urogenital disfunctions in the climacteric syndrome. Menopausal hormone therapy (MHT) with estrogens both in monotherapy and in combination with gestagenes is important when treating the climacteric syndrome. One should consider that MHT is effective in women at the early stages of the natural menopause in the period of open “therapeutic window”, whereas in elderly women with comorbidity the risk of adverse reactions increases for many times [17]. In view of the previously mentioned, modern medicine and pharmacy has an important task of development of new drugs, which could complement or adequately substitute MHT in case of contraindications in women, combining the effectiveness of hormonal drugs, minimal systemic adverse reactions and protecting the target organs.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
