Abstract
：Objective To observe theeffect of pulmonary circulation by 6% hydroxyethyl starch 130/0.4 during induction periodfrom epidural block combined with general anesthesia. Methods Twenty-six hepatobiliarysurgical patients with ASA Ⅰ-Ⅱ, aged 32 y-59 y, weighing 54kg-73 kg, were randomized into 2 groups(n=13): hydroxyethyl starch 130/0.4 group(HS)andcomplex acetic acid Ringer's solution (RL). Above-mentioned solutions were infused 7 ml/kgrespectively before induction. The pulmonary circulation hemodynamic parameters such aspulmonary arterial systolic pressure (PASP), pulmonary arterial diastolic pressure (PADP),mean pulmonary artery pressure(MPAP), pulmonary artery wedge pressure(PAWP), pulmonaryvascular resistance(PVR) and right ventricular stroke work(RVSW) were recorded at basevalue(T0), 10 min after infusion(T1), 5 min after induction(T2), 5 rain afterintubation(T3), 10 rain after intubation(T4)and 20 min after intubation(T5). Results PASP、PADP、MPAP、PAWP and CVP were significantlyhigher in group HS at T, than the values at T0 (P<0.05); PVR in group HS was obviouslylower from T1 to T5 than the value at To (P<0.05 or P<0.01); RVSW was significantlyhigher in two groups at T1 than base value (P<0.05), but that in group HS was lowerthan base value (P<0.05 or P<0.01); HR obviously decreased in two groups from T2 toT5 as compared with the value at T0 (P<0.05); MAP was lower from T3 to T5 than thevalue at To (P<0.05 or P<0.01). PVR was obviously lower in group HS from T1 to T5than that in group RL (P<0.05 or P<0.01); MAP obviously increased from T2 to T5 ingroup HS as compared with the value in group RL(P<0.05 or P<0.01). Conclusion 6%hydroxyethyl starch 130/0.4 can obviously reduce PVR during induction pe-riod fromepidural block combined with general anesthesia. In all, there is no effect on pulmonarycirculation by 6% hydroxyethyl starch 130/0.4. Key words: Hydroxyethyl starch; Epidural; General anesthesia; Induction period; Pulmonary circulation
Published Version
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