Abstract

This study was conducted to investigate the effects of 12weeks of aerobic exercise (AT) and saffron supplementation on hemostasis, inflammatory markers, and insulin resistance in obese women diagnosed with type 2 diabetes (T2D). A total of 44 women with T2D (mean age: 54.12±5.63years, mean BMI: 31.15±1.50kg/m2, HbA1c: 85±4.2mmol/mol) were included in a randomized, double-blind, placebo-controlled study. We were randomly assigned to one of four groups (n=11 per group): saffron+training (ST), placebo+training (PT), saffron supplement (SS), and placebo (P). The ST and PT groups completed 12weeks of AT (three sessions per week of mild to moderate intensity). The ST and SS groups were administered a daily dose of 200mg of saffron powder for 12weeks. Fasting blood samples were collected 48h before the first AT session and/or nutritional supplementation and 48h after the last AT session and/or nutritional supplementation. Post-evaluation, homeostatic model assessment of insulin resistance value (HOMA-IR, p<0.001) and serum levels of glucose (p<0.001), fibrinogen (FIB, p<0.001), homocysteine (HCY, p<0.001), interleukin-6 (IL-6, p<0.001), and tumor necrosis factor α (TNFα, p<0.001) showed significant reduction in the ST, PT, and SS groups compared to the P group (p<0.05). In particular, the ST group showed a more significant reduction in all variables compared to the PT and SS groups (p<0.05). Our results suggest that a 12-week intervention with AT and saffron supplementation can independently improve markers related to hemostasis, inflammation, and insulin resistance. However, their combination showed the greatest effectiveness on the above markers.

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