Abstract
IntroductionThe link of polycystic ovary syndrome (PCOS) with insulin resistance was subsequently established by clinical studies characterizing the profound insulin resistance in obese and lean PCOS patients.AimThe aim of this study was to compare the effect of aerobic exercise using an ergonomic treadmill on insulin resistance, body weight, and waist circumference in obese diabetic and nondiabetic women with polycystic ovary.Patients and methodsSixty obese women with PCOS, their age ranging from 30 to 40 years, participated in this study. All study participants were recruited from the Gynecology Outpatient Clinic of Kasr Al Aini Hospital. They were assigned into two equal groups: Group A (study group) included 30 obese diabetic women. Group B (control group) included 30 nondiabetic obese women.All patients received a controlled diet program and an aerobic exercise program (each exercise training session included continuous aerobic exercises on a treadmill for 30 min performed three times per week for 24 weeks under the supervision of physicians of the Faculty of Physical Therapy) and were on metformin drug (850 mg every 12 h).Fasting blood glucose, insulin resistance, and waist circumference were measured at the beginning of the study and after the study for both groups.ResultsStatistical analysis revealed a significant improvement in insulin resistance and waist circumference in both groups after the aerobic exercise training program.ConclusionRegular aerobic exercises improve insulin resistance, abdominal fat distribution, and body weight in obese diabetic and nondiabetic women with polycystic ovary, and they are advised to perform regular aerobic exercises.
Highlights
The link of polycystic ovary syndrome (PCOS) with insulin resistance was subsequently established by clinical studies characterizing the profound insulin resistance in obese and lean PCOS patients
An international consensus group proposed that the syndrome can be diagnosed by the determination of at least two of the following criteria: oligo-ovulation or anovulation, elevated levels of circulating androgens, or clinical manifestations of androgen excess; it is determined by ultrasonography, after the exclusion of other medical conditions that cause irregular menstrual cycles and androgen excess [2]
(2) Two of the following three signs were present for the diagnosis of PCOS: (a) Clinical or biochemical hyperandrogenemia. (b) Menstrual irregularity. (c) Polycystic ovarian morphology on ultrasound defined as increased ovarian mass more than 5.5 cm2/ovary or volume more than cm3/ ovary and/or or more follicles measuring 2–9 cm in diameter
Summary
The link of polycystic ovary syndrome (PCOS) with insulin resistance was subsequently established by clinical studies characterizing the profound insulin resistance in obese and lean PCOS patients. Aim The aim of this study was to compare the effect of aerobic exercise using an ergonomic treadmill on insulin resistance, body weight, and waist circumference in obese diabetic and nondiabetic women with polycystic ovary. All study participants were recruited from the Gynecology Outpatient Clinic of Kasr Al Aini Hospital. They were assigned into two equal groups: Group A (study group) included 30 obese diabetic women. Because women with the PCOS typically have hyperinsulinemia, the concentration of free testosterone is often elevated when the total testosterone concentration is at the upper range of normal or just elevated [5]
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