Abstract
Methods C57BL/6 mice were treated with porcine thyroglobulin and Freund’s adjuvant both in the simple model group and the BM-MSCs treated group. Mice in the BM-MSCs treated group were injected with homology BM-MSCs (3×10/mouse) at the beginning of model establishment. A normal control group was set as well. All mice were killed at the 28th day after primary immunity. The histopathological analysis of thyroid tissues were observed. The levels of autoantibodies, thyroid hormone, IFN-r, IL-10 were detected.
Highlights
C57BL/6 mice were treated with porcine thyroglobulin and Freund’s adjuvant both in the simple model group and the BM-MSCs treated group
Mice in the BM-MSCs treated group were injected with homology BM-MSCs (3×105/mouse) at the beginning of model establishment
All mice were killed at the 28th day after primary immunity
Summary
From 8th APPES Biennial Scientific Meeting Darwin, Australia. 29 October – 1 November 2014. From 8th APPES Biennial Scientific Meeting Darwin, Australia. Aims To investigate the effect and the mechanism of allobone marrow mesenchymal stem cells (BM-MSCs) transplantation in the Experimental Autoimmune Thyroiditis (EAT) mouse model
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