Abstract
VARIOUS products of the anaphylactic reaction such as the ECF-A tetrapeptides1 (Val-Gly-Ser-Glu and Ala-Gly-Ser-Glu)2 and histamine3,4 preferentially attract the human eosinophil in chemotaxis in vitro. We have designed experiments to show whether these chemical mediators have a direct effect on the eosinophil cell membrane, as assessed by their capacity to alter receptors for either IgG or complement (C). We have established here that these two ECF-A peptides and histamine both enhance markedly the expression of eosinophil receptors for C3 but not for IgG. Neutrophil and monocyte receptors seemed to be unaltered and a number of other chemical mediators of hypersensitivity had no effect on these membrane markers when tested at comparable concentrations. Our demonstration of eosinophil membrane receptor enhancement by chemotactic factors may have more general biological significance in terms of how surface recognition mechanisms by phagocytic cells are regulated.
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