Abstract
Abstract Human eosinophils and neutrophils were shown to have receptors for rabbit and human IgG, and for the human complement components C4, C3b, and C3d (A. R. E. Anwar and A. B. Kay (1977), J. Immunol. 119: 976, 1977. We now report that agents which have a selective effect on human eosinophil motility in vitro, such as the ECF-A peptides and histamine, also enhance the number of receptors for C3b and C4, but not for IgG and C3d. The ECF-A tetrapeptides (Val-Gly-Ser-Glu and Ala-Gly-Ser-Glu) and histamine increased the percentage of eosinophils forming rosettes with EAC3b by approximately 90%, an effect that was observed in a dose- and time-dependent fashion. Neutrophil and monocyte C3b receptors were unaltered by this treatment and other pharmacologic agents such as bradykinin and the prostaglandins E1, E2, and F2α were without effect on any of the cell types when tested in the dose range 10-4 to 10- mole/1.
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