The early diagnostic value of IAP combined with IFABP for patients with mechanical ventilation complicated with AGI

Abstract

Objective To investigate the early diagnostic value of intra-abdominal pressure (IAP) combined with intestinal fatty acid binding protein (IFABP) for patients with mechanical ventilation complicated with acute gastrointestinal injury (AGI). Methods From August 2015 to December 2015, 119 patients with mechanical ventilation were admitted to ICU in our hospital, with 78 cases of AGI patients and 41 cases of non- AGI patients. Multiple physiological indexes and laboratory indexes of the two groups were recorded and compared. Results There was no statistical difference in sex, age, APACHE II score, BMI index, Lac and mean arterial pressure (MAP) between the two groups (P>0.05); the OR values of mechanical ventilation time, oxygenation index, end-expiratory positive pressure (PEEP), CIT, IFABP and IAP were more than 1, so these indicators were all risk factors for AGI in patients with mechanical ventilation. The area under the curve of IAP, IFABP, mechanical ventilation and PEEP were more than 0.5, indicating that these indicators have a certain predictive value for AGI patients with mechanical ventilation. The sensitivity and specificity of IAP were 95% and 80% respectively, and the sensitivity and specificity of IFABP were 87.5% and 50%, respectively. IAP was correlated with IFABP (r = 0.621, P = 0.031). Conclusions Mechanical ventilation time, oxygenation index, PEEP, CIT, IFABP, and IAP are risk factors for AGI patients with mechanical ventilation. IAP, IFABP, mechanical ventilation time and PEEP have a certain predictive value for AGI patients with mechanical ventilation. The diagnostic value of IAP and IFABP is high, and the two are closely related. Combined application can provide a certain objective basis for clinical AGI diagnosis. Key words: Mechanical ventilation; Acute gastrointestinal injury; Intra-abdominal pressure; Intestinal fatty acid binding protein; Citrulline