The Earliest Cortical Circuits

Abstract

Event Abstract Back to Event The Earliest Cortical Circuits Zoltan Molnar1*, Anna Hoerder-Saubedissen1, Wei Zhi-Wang1, Maria Carmen-Pinon1 and Franziska Oeschger1 1 University of Oxford, Department of Physiology, Anatomy and Genetics, United Kingdom Building the brain is like a house of cards. The early connections provide the foundation of the adult structure, and disruption of these may be the source of many developmental flaws. Cerebral cortical developmental disorders (including schizophrenia and autism) and perinatal injuries involve cortical neurons with early connectivity, and the major hindrance of progress in understanding the early neural circuits during cortical development and disease was a lack of reliable markers for specific cell populations. Due to the advance of powerful approaches in gene expression analysis and the utility of models with reporter gene expressions in specific cortical cell types our knowledge of the early cortical circuits is rapidly increasing. This field benefited from recent developments in mouse genetics in generating models with subtype specific gene expression patterns, powerful cell dissection and separation methods combined with microarray analysis. With focus on the rodent subplate we shall illustrate the progress made in the understanding of their integration into the early intracortical and extracortical circuitry during normal and altered cortical development. We shall review how the emergence of the subplate cell type specific markers started to have an impact on comparative studies and neuropathological diagnosis. Conference: INMED Satellite Conference of SFN - Neuroscience 2009, Multiple Facets of GABA in Brain Development, Chicago, United States, 16 Oct - 16 Oct, 2009. Presentation Type: Oral Presentation Topic: Abstracts Citation: Molnar Z, Hoerder-Saubedissen A, Zhi-Wang W, Carmen-Pinon M and Oeschger F (2009). The Earliest Cortical Circuits. Conference Abstract: INMED Satellite Conference of SFN - Neuroscience 2009, Multiple Facets of GABA in Brain Development. doi: 10.3389/conf.neuro.03.2009.13.008 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 23 Jul 2009; Published Online: 23 Jul 2009. * Correspondence: Zoltan Molnar, University of Oxford, Department of Physiology, Anatomy and Genetics, Oxford, United Kingdom, zoltan.molnar@human-anatomy.oxford.ac.uk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Zoltan Molnar Anna Hoerder-Saubedissen Wei Zhi-Wang Maria Carmen-Pinon Franziska Oeschger Google Zoltan Molnar Anna Hoerder-Saubedissen Wei Zhi-Wang Maria Carmen-Pinon Franziska Oeschger Google Scholar Zoltan Molnar Anna Hoerder-Saubedissen Wei Zhi-Wang Maria Carmen-Pinon Franziska Oeschger PubMed Zoltan Molnar Anna Hoerder-Saubedissen Wei Zhi-Wang Maria Carmen-Pinon Franziska Oeschger Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.