Abstract
Event Abstract Back to Event Behavioral and Electrophysiological Correlates of Novelty Detection in Mouse Auditory Cortex Jose Garcia-Lazaro1*, I. Nelken2 and J. W. Schnupp1 1 Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom 2 The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Israel In order to study the interactions between the behavioural and electrophysiological aspects of the processing of novel stimuli, we measured evoked epidural potentials from anesthetized (2-2-2-tribromoethanol/tert-amyl alcohol) C57BL6 mice in the oddball paradigm. Evoked local field potential responses were recorded epidurally from auditory cortex using custom-built low impedance electrodes. Acoustic stimuli consisted on 30 ms tone pips presented once every 300 ms. Two different frequencies, 6.67 kHz and 13.7 kHz, were presented in a randomly interleaved manner. In one condition, one of these frequencies was presented as a standard, with a 90% probability and the other as a deviant, with 10% probability. In a second condition, these probabilities were reversed. We recorded responses to 1000 repeats for each condition. Our preliminary data shows a strong oddball effect. Although this effect was observed for both frequencies, it was significantly stronger for the larger frequency. In order to investigate the potential role of experience, we also measured electrophysiological responses from animals after avoidance training. Training was entirely automated using a simplified version of the Intellicage system (NewBehavior AG, Zurich, Switzerland). The system operates using transponder technology for individual animal recognition and contains an isolated test chamber where mice obtain drinking water by triggering a nose-poke hole. In our paradigm, on 75% of the times an animal visited the chamber, a standard (6.67 kHz) sound stimulus was presented. The stimulus consisted on tone pips presented at intervals of 300 ms for 5 seconds. On the remaining 25% of the visits, a deviant (13.7 kHz) sound stimulus was presented. During a deviant visit animals did not obtain water, but instead a mildly aversive air-puff. Preliminary electrophysiological data from behaviorally trained animals shows that while potentials recorded in response to the standard (non-aversive) stimulus remained largely unchanged, potentials recorded in response to the aversive stimulus exhibited a two-fold increase in amplitude. These differences in the responses following training represent the prima facie evidence for experience induced changes in mouse auditory cortex. Supported by an EU FP6 project grant (LSHM-CT-2006-037378). Conference: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009. Presentation Type: Poster Presentation Topic: Poster Presentations Citation: Garcia-Lazaro J, Nelken I and Schnupp JW (2009). Behavioral and Electrophysiological Correlates of Novelty Detection in Mouse Auditory Cortex. Conference Abstract: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications. doi: 10.3389/conf.neuro.09.2009.05.080 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 25 Mar 2009; Published Online: 25 Mar 2009. * Correspondence: Jose Garcia-Lazaro, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, jose.garcia-lazaro@dpag.ox.ac.uk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Jose Garcia-Lazaro I. Nelken J. W Schnupp Google Jose Garcia-Lazaro I. Nelken J. W Schnupp Google Scholar Jose Garcia-Lazaro I. Nelken J. W Schnupp PubMed Jose Garcia-Lazaro I. Nelken J. W Schnupp Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have