The ‘Dynamic’ Marriage Between Varicella and Zoster

Pieter T De Boer,Jan C Wilschut,Maarten J Postma

doi:10.1016/j.ebiom.2015.09.014

Pieter T De Boer, Jan C Wilschut + Show 1 more

Open Access

https://doi.org/10.1016/j.ebiom.2015.09.014

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Abstract

The ‘Dynamic’ Marriage Between Varicella and Zoster

Highlights

Van Lier et al analysed the cost-effectiveness of varicella vaccination in the Netherlands using dynamic modelling with the Hope-Simpson hypothesis included and excluded (Van Lier et al, 2015)
Inclusion of the boosting hypothesis, results in dominance for the no varicella vaccination policy, because varicella vaccination would result in higher costs and quality-adjusted life years (QALYs) losses due to an increase of herpes zoster (HZ) in the adult population
Prior to the current study of Van Lier et al, four studies have analysed the impact of varicella vaccination on HZ using dynamic modelling (Damm et al, 2015)

Summary

Introduction

Van Lier et al analysed the cost-effectiveness of varicella vaccination in the Netherlands using dynamic modelling with the Hope-Simpson hypothesis included and excluded (Van Lier et al, 2015). Without the Hope-Simpson hypothesis, varicella vaccination is highly cost-effective or even costsaving with major gains of quality-adjusted life years (QALYs). Inclusion of the boosting hypothesis, results in dominance for the no varicella vaccination policy, because varicella vaccination would result in higher costs and QALY losses due to an increase of HZ in the adult population.

Results

Conclusion