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Abstract
SUMMARYThe Djungarian hamster, Phodopus sungorus, is an organism used extensively in biomedical research. In this investigation, it was examined for its suitability for the in vivo study of sister chromatid exchange (SCE). Bromodeoxyuri- dine (BrdU) incorporation was performed by subcutaneous implantation of a commercially prepared 50 mg slow-release pellet, and sister chromatid differential staining was performed using incandescent light exposure of bone marrow metaphase cells. SCE frequency was markedly increased in animals injected with cyclophosphamide (CP). Cells of P. sungorus treated with this method showed clear and distinct sister chromatid differential staining, indicating that this organism is suitable for the in vivo study of SCE.
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