Abstract
The cell membrane has gained significant attention as a platform for the development of bio-inspired nanodevices due to its immune-evasive functionalities and copious bio-analogs. This review will examine several uses of cell membranes such as (i) therapeutic delivery carriers with or without substrates (i.e., nanoparticles and artificial polymers) that have enhanced efficiency regarding copious cargo loading and controlled release, (ii) exploiting nano-bio interfaces in membrane-coated particles from the macro- to the nanoscales, which would help resolve the biomedical issues involved in biological interfacing in the body, and (iii) its effects on the mobility of bio-moieties such as lipids and/or proteins in cell membranes, as discussed from a biophysical perspective. We anticipate that this review will influence both the development of novel anti-phagocytic delivery cargo and address biophysical problems in soft and complex cell membrane.
Highlights
Current Stages of Membranes World in Drug CarriersCell membranes are highly complex dynamic systems with compositional heterogeneity that utilize several types of phospholipids and proteins as major constituents
The cell membrane has gained significant attention as a platform for the development of bio-inspired nanodevices due to its immune-evasive functionalities and copious bio-analogs
It is responsive to external stimuli such as chemical [1,2,3], mechanical forces [4,5,6], electrical [4,7,8,9], and thermal stresses [10,11], and functions by communicating with other cell membranes and transporting signals in a harmonious manner without the disrupting of the membrane
Summary
Cell membranes are highly complex dynamic systems with compositional heterogeneity that utilize several types of phospholipids and proteins as major constituents. Cellular functions such as immunological impact, there have been attempts to coat biodegradable PLGA.
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