Abstract
FROM OBSERVATIONS made in this laboratory (Franklin, Chaikoff and Lerner, 1944) it was concluded that thiocyanate inhibits the iodine concentrating capacity of thyroid tissue in vitro. This conclusion was based on experiments in which surviving slices of thyroid tissue were suspended in a Ringer medium containing radioactive inorganic iodide (I131) as a labeling agent. More recently the goitrogenic action of thiocyanate in vivo has been investigated by Rawson, Tannheimer and Peacock (1944). These workers measured the uptake of radioactive iodine by rat thyroids that had been made hyperplastic by the administration of thiocyanate Average values of 56 and 87 per cent of the injected radioactivity were recovered in the thyroid gland of the control and thiocyanatetreated animals respectively. In view of the apparent discrepancy between the in vitro and in vivo effects of thiocyanate, the action of this goitrogen on iodine metabolism has been reinvestigated.
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