Abstract
The concentrations of most free amino acids in red cells increase during pregnancy simultaneously with a decrease in the plasma amino acids, which results in significantly higher erythrocyte/plasma distribution ratios at delivery for all amino acid groups studied except threonine + glutamic acid. The plasma amino acids are significantly higher in fetal than in maternal plasma. Thus an active transport of amino acids through the placenta against a concentration gradient and an increased cellular uptake of amino acids both contribute to the low plasma amino acid values found in pregnancy. All amino acid groups studied in pregnant females at delivery show significantly higher distribution ratios than simultaneous blood specimens from the fetus. The erythrocyte/plasma amino acid ratios in fetal blood are similar to those found in non-pregnant females.
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