The discharge of a subset of serotonergic raphe magnus cells is influenced by baroreceptor input

Abstract

In order to determine whether serotonergic cells in the medullary raphe magnus (RM) receive baroreceptor input, cells were tested for their responses to descending aortic occlusion, aortic nerve stimulation, or systemic phenylephrine administration in the lightly anesthetized rat. Serotonergic cells were identified physiologically by a quantitative analysis of their slow and steady discharge. Greater than 40% of the serotonergic RM cells tested responded to brief occlusion of the descending aorta at the level of the coeliac arteries, a stimulus that elevated blood pressure by about 30 mmHg. Similarly, about 40% of the serotonergic RM cells responded to stimulation of the aortic nerve, a nerve that contains primarily baroreceptor afferents from the aortic arch. Greater than 70% of RM serotonergic cells responded to phenylephrine administration which elevated blood pressure by an average of 50 mmHg. Serotonergic cell responses to all methods of baroreceptor activation were small in magnitude and were largely restricted in time to the stimulus duration. The results indicate that a subset of serotonergic cells in RM are influenced by baroreceptor activity.