Abstract
In this study, the diffusion characteristics of diclofenac-Na through hydrophobic and hydrophilic polyurethane (PU)-based membranes are investigated. Hydrophilic polymers are obtained by graft copolymerization of PU with acriylamide (AAm) and itaconic acid (IA). The membranes are prepared by a solvent-casting method and characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) analysis. The diffusion measurements are performed using a diffusion cell for 10 h at 37°C. Permeability coefficients calculated from diffusion experiments are ∼3 times higher in hydrophilic membranes than hydrophobic PU membranes. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 85: 193–198, 2002
Published Version
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