Abstract
In the work with oxygen exposed animals, it is readily apparent that there are great differences in the responses of young and old animals. Young rats are far more resistant to oxygen poisoning than are older rats. The younger animals, weighing 90-110 grams (about four weeks old) will live in 100% oxygen at one atmosphere for long periods of time, many surviving for four to six weeks. On the other hand, larger rats, 300-350 grams (12-16 weeks old) live only about three days in the same atmosphere. Obviously, changes must occur at a greater rate, they may be more damaging and may even be different in character.Rats in the 90-110 gram range and in the 300-350 gram range were exposed for 48 hours to pure oxygen at one atmosphere. The animals were sacrificed, the tissue removed, cut into small blocks and fixed in glutaraldehyde, followed by osmium post-fixation.
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