The diagnostic value of serum AMH, IGF-1 and IGFBP-1 levels in polycystic ovarian syndrome

Abstract

Objective To explore the relation between serum AMH, IGF-1 and IGFBP-1 levels and polycystic ovarian syndrome (PCOS) and its clinical significance. Methods Serum levels of AMH, IGF-1 and IGFBP-1 were measured by ELISA in 80 patients with PCOS and 80 healthy subjects. Results The levels of serum AMH, IGF-1, IGFBP-1 in PCOS group were (7.18±1.50)ng/L, (200.85±27.78)ng/L, (4.05±0.65)ng/L respectively, which in the control group were (3.70±1.01)ng/L, (110.58±12.50)ng/L, (8.16±1.39)ng/L.The serum levels of AMH, IGF-1 in the PCOS group were significantly higher than those in the control group(t=13.14, 26.80, P<0.01), while the serum level of IGFBP-1 in the PCOS group was significantly lower than that in the control group(t=16.28, P<0.01). The serum levels of AMH, IGF-1, IGFBP-1 in patients with obese group were (7.18±1.50)ng/L, (200.85±27.78)ng/L, (4.05±0.65)ng/L respectively, which in the non-obese group were (15.52±2.41)ng/L, (143.85±15.61)ng/L, (6.75±0.93)ng/L.The serum level of IGF-1 in the obese group was significantly higher than that in the non-obese group(t=10.87, P<0.01), while the serum levels of AMH and IGFBP-1 in the obese group were significantly lower than those in the non-obese group(t=18.98, 15.27, P<0.01). Conclusion Serum AMH, IGF-1 and IGFBP-1 may be involved in the pathogenesis and obesity of PCOS, which may be associated with the pathogenesis of PCOS. Key words: Polycystic ovarian syndrome; Anti-mullerian hormone; Insulin-like growth factor 1; Insulin-like growth factor binding protein1; Obesity