The Diagnostic Role of Adiponectin in Pulmonary Embolism.

Evrim Gul,Ömer Doğan Alataş,Mehmet Nuri Bozdemir,Bengü Mutlu,Yeliz Gul,Mustafa Yıldız,Necip İlhan,Mehmet Ruhi Onur,Feti Yıldız,Ersin Yıldırım,Mustafa Safa Pepele

doi:10.1155/2016/6121056

Abstract

Background and Aims. Pulmonary thromboembolism (PTE) is a frequent disease with difficult diagnosis and high mortality. Misdiagnosis occurs in 2/3 patients and mortality rates reach up to 30%. The aim of our study was to investigate the role of adiponectin used in emergency service in diagnosis of PTE. Materials and Methods. 95 patients with suspected PTE included in the study. Plasma adiponectin and D-dimer levels were measured and chest X-ray and multidetector row computed tomography scan obtained. Diagnosis was supported by vascular filling defect on tomography. Control group consisted of patients with suspected PTE and normal chest computed tomography findings. Results. Mean D-dimer level was 4241.66 ± 1082.98 ng/mL in patients and 2211.21 ± 1765.53 ng/mL in the control group (p ≤ 0.05). Mean adiponectin level was 5.46 ± 4.39 μg/mL in patients and 7.68 ± 4.67 μg/mL in the control group (p ≤ 0.05). Wells and Geneva scores were higher in patients compared to the control group. Conclusions. As a result, we conclude that lower adiponectin levels have an important role in the diagnosis of PTE.

Highlights

Pulmonary thromboembolism (PTE) refers to the migration of a blood clot from systemic deep veins into the pulmonary vascular bed
The diagnosis of pulmonary thromboembolism was made based on its compatibility with filling defect of PTE on multidetector computed tomography (MDCT) according to predefined standard protocol
The control group involved patients presenting to the emergency department with a suspicion of pulmonary embolism, yet this could not be detected on a Thorax CT scan

Summary

Introduction

Pulmonary thromboembolism (PTE) refers to the migration of a blood clot from systemic deep veins into the pulmonary vascular bed. It is a common occurrence with high mortality rates and presents itself as being difficult to diagnose [1]. Control group consisted of patients with suspected PTE and normal chest computed tomography findings. Mean adiponectin level was 5.46 ± 4.39 μg/mL in patients and 7.68 ± 4.67 μg/mL in the control group (p ≤ 0.05). Wells and Geneva scores were higher in patients compared to the control group. We conclude that lower adiponectin levels have an important role in the diagnosis of PTE

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Conclusion