Abstract
ObjectiveTo detect the levels of signal transducer and activator of transcription 4 (STAT4) and soluble endoglin (sEng) in preeclampsia patients and analyze the diagnostic values of STAT4 and sEng in preeclampsia.MethodsFifty‐four pregnant women with preeclampsia from October 2017 to June 2018 were included in this study. Twenty‐eight matched healthy pregnant women were set as the control group. The general clinical characteristics were measured. Serum STAT4 and sEng were detected by ELISA. Correlation between STAT4 and sEng, and their diagnostic value in preeclampsia were analyzed.ResultsCompared with control, the prothrombin time in preeclampsia was significantly lower, while the mean arterial pressure, 24‐hour urine protein, serum creatinine, fibrinogen, and ALT were significantly higher. The circulating levels of STAT4 and sEng were significantly increased in the preeclampsia. The serum levels of STAT4 and sEng in preeclampsia were positively correlated. For the diagnosis of preeclampsia by the serum STAT4, AUC is 0.902, and the sensitivity and specificity are 0.893 and 0.929. By the serum sEng, AUC is 0.873, and the sensitivity and specificity are 0.816 and 0.905.ConclusionThe serum levels of STAT4 and sEng were significantly increased in preeclampsia with disease severity status, which have promise as diagnostic markers in preeclampsia.
Highlights
Preeclampsia is a special disease of pregnancy, which occurs after 20 weeks of pregnancy.[1]
We reported that signal transducer and activator of transcription 4 (STAT4) and soluble endoglin (sEng) involved in preeclampsia
The clinical manifesta‐ tions are characterized by hypertension and proteinuria, accompa‐ nied by multiple organ damage
Summary
Preeclampsia is a special disease of pregnancy, which occurs after 20 weeks of pregnancy.[1] It is characterized by hypertension and proteinuria, which can cause serious complications such as cerebral edema, pulmonary edema, cerebral hemorrhage, heart failure, coag‐ ulopathy, liver rupture, placental abruption, fetal growth restriction, and fetal death. The abnormality of trophoblast invasion, the theory of endothelial cell injury, the theory of genetic susceptibility, the theory of renin‐an‐ giotensin‐aldosterone, dysregulation of coagulation and fibrinolysis system, and theory of nutritional deficiencies, insulin resistance, and environmental factors.[6-9]. These theories are frequently integrated and interrelated with each other. This study analyzed the expression of STAT and sEng in the pre‐ eclampsia and normal pregnancy patients, and the relationship be‐ tween STAT4 and sEng in preeclampsia
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