Abstract
Pulp regeneration is one of the most successful areas in the field of tissue regeneration, despite its current limitations. The biocompatibility of endodontic biomaterials is essential in securing the oral microenvironment and supporting pulp tissue regeneration. Therefore, the objective of this study was to investigate the new light-curable calcium silicate (CS)-containing polyethylene glycol diacrylate (PEGDA) biocomposites’ regulation of human dental pulp stem cells (hDPSCs) in odontogenic-related regeneration. The CS-containing PEGDA (0 to 30 wt%) biocomposites are applied to endodontics materials to promote their mechanical, bioactive, and biological properties. Firstly, X-ray diffraction and Fourier-transform infrared spectroscopy showed that the incorporation of CS increased the number of covalent bonds in the PEGDA. The diameter tension strength of the CS-containing PEGDA composite was significantly higher than that of normal PEGDA, and a different microstructure was detected on the surface. Samples were analyzed for their surface characteristics and Ca/Si ion-release profiles after soaking in simulated body fluid for different periods of time. The CS30 group presented better hDPSC adhesion and proliferation in comparison with CS0. Higher values of odontogenic-related biomarkers were found in hDPSCs on CS30. Altogether, these results prove the potential of light-curable CS-containing PEGDA composites as part of a ‘point-of-care’ strategy for application in odontogenesis-related regeneration.
Highlights
The main purpose of endodontic surgery is to seal tooth defects with suitable root canal filling materials to prevent bacterial overgrowth and colonization [1]
Different concentrations of light-curable were prepared were loaded with human dental pulp stem cells (hDPSCs), cast in pre-fabricated molds, and cured using UV according light. to the methods described in the section above
The fabricated light-curable Calcium silicate (CS) composites. This concept arose from the idea that we could inject the light-curable CS into tooth defects were loaded with hDPSCs, cast in pre-fabricated molds, and cured using UV light
Summary
The main purpose of endodontic surgery is to seal tooth defects with suitable root canal filling materials to prevent bacterial overgrowth and colonization [1]. The ideal root canal filling material should have excellent biocompatibility, bioactivity, sealing capability, X-ray opacity, and antibacterial properties [3]. Mineral trioxide aggregate (MTA) is one of the most widely used filling materials for root canal treatment [4]. Even though MTA is a popular material for dental applications, a main disadvantage of MTA is that it has a long curing duration of at least 2–5 h. MTA is often used in patients with massive gum bleeding, its long curing duration greatly decreases its sealing performance for bleeding patients [7]
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