The Development of Hemochromatosis after Treatment for Celiac Sprue

Mang Ma,Vincent G Bain,Edmond A Ryan

doi:10.1155/1994/128687

Abstract

Celiac sprue is a chronic disease characterized by maldigestion and malabsorption. Whereas many diseases have been reported in association with celiac sprue, hemochromatosis has not. A 62-year-old man with celiac sprue and a history of iron deficiency and osteopenic bone disease who developed hemochromatosis is reported. Liver biopsy showed portal tract fibrosis, early nodule formation and increased hepatic iron storage. The patient developed hemochromatosis with hepatic injury two years after his transferrin saturation became elevated and 10 years after he had been placed on gluten-free diet. Lifelong iron accumulation was prevented by chronic malabsorption of iron but hemochromatosis became manifest when his celiac sprue was treated.

Highlights

Patients with proximal small intC "tine involvement can present with iron deficiency, folate deficiency or osteopen ic bone disease
These deficiencies can be corrected after treatment with gluten-free diet
We report the ca e of a 62-yearold male who developed hem chromato is after being treated fo r ce liac sprue with a gluten -free diet

Summary

The developtnent of hetnochrotnatosis after treattnent for celiac sprue

A 62-year-old man with celiac sprue and a history of iron deficiency and osteop nic bone disease who developed hemochromatosis is reported. The patient developed hemochromatosis with hepatic injury two years after his transferrin saturation became elevated and 10 years after he had been placed t n gluten-free diet. Patients with proximal small intC "tine involvement can present with iron deficiency, folate deficiency or osteopen ic bone disease These deficiencies can be corrected after treatment with gluten-free diet. We report the ca e of a 62-yearold male who developed hem chromato is after being treated fo r ce liac sprue with a gluten -free diet This case a l o prov ides insight into the time required fo r hepatic injury secondary to iron overload ing

CASE PRESENTATION

DISCUSSION