Abstract
The lipophilicity of a substance is an important physicochemical parameter for the pharmacological activity of a drug. In the current study, high-performance thin-layer chromatography was applied to determine the LogP values of the following anticoagulant drugs: warfarin, acenocoumarol, clopidogrel, and prasugrel. The mobile phase was a mixture of acetonitrile and water in mixed proportions. The content of acetonitrile varied from 50% to 80% in 5% increments. The partition coefficients were calculated with the regression curve Rm0 = f(LogP) based on the compounds with known lipophilicity. The highest LogP was observed for warfarin and the lowest for prasugrel.
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