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Abstract
Meeting Abstracts1 May 1971The Detection of Intravascular Coagulation by a Serial Dilution Protamine Sulfate Test.V. Gurewich, M.D., F.A.C.P., S. Niewiarowski, M.D., E. Hutchinson, B.S., J. Gajewski, M.D.V. Gurewich, M.D., F.A.C.P.Search for more papers by this author, S. Niewiarowski, M.D.Search for more papers by this author, E. Hutchinson, B.S.Search for more papers by this author, J. Gajewski, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-826_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn vitro studies demonstrated that when serial dilutions of a 1% stock solution of protamine sulfate are added to plasma, the appearance of fibrin strands or gelation (paracoagulation) was specific for fibrin monomers and early fibrin degradation products. The test was sensitive to 1 mg/100 ml fibrin monomers and less than 1 mg/100 ml fibrin degradation products. The test utilizes much lower concentrations of protamine sulfate than previously used, which allows fibrin monomers and early fibrin degradation products to polymerize. Fibrinogen and fibrinogen degradation products did not influence the test. The test was considered positive only when fibrin strands appeared,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5Page: 826-826KeywordsAttentionBlood plasmaFibrinFibrinogenProtamines Issue Published: 1 May 1971 PDF DownloadLoading ...
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