Abstract
An acid mucopolysaccharide was found in the blood and urine of a three year old child with metastatic nephroblastoma. A compound similar to if not identical with hyaluronic acid was isolated. Although the urine was not fractionated, it contained a testicular hyaluronidase-sensitive acid mucopolysaccharide presumably similar to the one isolated from the serum. Laboratory findings which prompted the investigation were rapid blood sedimentation rate, agglutination of leukocytes in the counting chamber, rouleaux formation, strands of acidophilic material on the routine peripheral blood smear and the formation of a precipitate upon acidification of the serum. The unusual characteristics of the serum disappeared after incubation with testicular hyaluronidase.
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