Abstract
The dereplication of natural products is gaining greater importance in optimizing the process of natural product drug discovery as the pace of evaluating natural product extracts for their biological potential has increased. Over the years, as new technologies are introduced into analytical chemistry, they have been applied to detect known compounds before isolation and structure elucidation is initiated. Initially, chromogenic reagents were used to obtain information on the chemical classes of compounds found in natural product extracts. Though not very powerful in predictive nature as to the identity of compounds present, chemical class information was used in order to prioritize natural product extracts for subsequent isolation. The power of partially separating extracts with paper and thin-layer chromatographic techniques before subsequently spraying with chromogenic reagents, increased the ability of researchers to distinguish different classes of compounds from one another. TLC techniques were of major importance to many natural product drug discovery groups and are still widely used today. One of the most critical technologies to become available in the past decade and to advance the prioritization process is that of the computer. With the advent of small and powerful computers, information that is widely distributed and difficult to search, is now readily searchable by using any desired parameter such chemical, taxonomic, or pharmacological.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call