The Dark Side of Acid Suppression: Exploring Mood Changes in Omeprazole treated Mice

Abstract

Depression is considered as one of the most common major health obstacles in the communities, according to World Health Organization (WHO) about 3.8% of population are suffering from depression. The prevalence of depression in Libya is 23.68%, excluding other mental and psychiatric disorders. Few studies and experiments bay attention about the significance of pharmacological cause of depression. The researchers have turned their focus to the association between Proton pump inhibitors (PPIs) and depression and suicidal attempts, which are considered as one of the most common prescribed drugs and can be sold without prescriptions in some nations. The aim of Study is assessment omeprazole's possible depressive-like effects on experimental animals. Behavioral tests: the tail suspension test (TST), forced swim test (FST), and sucrose preference test (SPT) were used to evaluate different behavioral changes in male Swiss albino mice after they were given omeprazole (40 mg/kg) for 15 days. According to our findings, the omeprazole (40 mg/kg) had a significant effect (p < 0.01) on the tail suspension test and the forced swim test, and both tests had longer immobility times. An indicator of anhedonia, sucrose preference, was dramatically reduced by omeprazole (p value < 0.01). A one-way ANOVA of the body weight data showed that it was not significant (p > 0.05). Concerns about the long-term use of omeprazole are raised by the depressive-like effects seen in this study, especially in patients who may be taking the drug for longer periods of time. However, the supporting evidence remains limited, necessitating further research to comprehensively understand the implications of these drugs on mental health.