THE DAILY EXCRETION OF CATECHOLAMINES IN THE URINE OF NORMOTENSIVE PATIENTS WITH DIABETES WITHOUT HYPERTENSION

Abstract

As you know, judge the state of the tone and reactivity of SAS allows the study of the excretion of the catecholamines (KA), of metabolic products of biogenic amines and enzymes involved in their metabolism. More informative and appropriate for clinical trials is a systematic approach to the study of SAS, including simultaneous determination of excretion of the precursor of the synthesis of KA - DOPA and its spectrum: dopamine (DA), noradrenaline (NA) and adrenaline (A) [8]. In available for us literature data on this problem is quite contradictory and relates to certain aspects of these studies. Installed as the decrease or increase in the level of CA in blood and urine, as in type 2 diabetes [4,5] and in hypertension [7,8,9]. There are no works devoted to the study of the qualitative and quantitative assessment of the functional state of the sympathetic-adrenal system, i.e. excretion of KA and their precursors and activity of monoamine oxidase (MAO) when combined with diabetes 2-type with AG. It is known that one of the processes that lead to the disruption of the cell membrane is the activation of processes of peroxide oxidation of lipids (Pol). Excessive formation of free radicals, accumulation of primary and secondary products of lipoperoxidation weakens the hydrophobic membrane when the body's cells, in particular β-cells of the islets of Langerhans, which leads ultimately to the suppression of proinsulin synthesis and cell death [5]. From the foregoing it is obvious that the state of the sympathetic-adrenal system and processes of lipid peroxidation in type 2 diabetes with hypertension has been insufficiently studied, and the available results are contradictory. Accordingly, this issue remains controversial. An urgent task is the development of optimal approaches to the treatment of hypertension in patients with type 2 diabetes. Ideally, such a drug should have a good antihypertensive effect, but must be at least metabolically neutral. In this regard, of great interest is the class of imidazoline receptor agonists, which not only reduce sympathetic activity and blood pressure (BP), but also have a positive effect on insulin resistance, lipid and glucose metabolism [6,7]. However, the influence of treatment with moxonidine on the functional activity of the sympathetic-adrenal system studied, not studied and the processes of lipid peroxidation on the background of treatment with agonists of imidazoline receptors. On this basis, undertaken the present study