Features of the Functional State of the Hypophysis-Ovarian System and Processes of Lipid Peroxidation – Antioxidant Protection in Women with Hyperandrogenism of Ovary Genesis in the Early Reproductive Period

Abstract

Background . Women with polycystic ovary syndrome in the early reproductive period have hormonal and metabolic dysfunction and an increased risk of long-term health consequences. The article presents the results of the study of hormonal indicators and the parameters of lipid peroxidation – antioxidant protection in women with polycystic ovary syndrome in early period of reproductive age (from 18 to 35 years old). Aim : evaluation of the functional state of the pituitary-ovarian-adrenal system and the lipid peroxidation – antioxidant protection system and the establishment of intersystemic relationships in women of the early reproductive period with polycystic ovary syndrome. Materials and methods . Study included 33 women with ovarian hyperandrogenism and 17 healthy women of early reproductive age. A questionnaire survey, general medical and gynecological examinations, and ultrasound examination of the pelvic organs were conducted. Immunoenzyme method for detection the concentration of hormones, spectrophotometric and spectrofluorometric (determination of the concentration of lipoperoxidation products, parameters of antioxidant protection), statistical methods were used. Results . Women of early reproductive age (from 18 to 35 years old) with polycystic ovary syndrome characterized by an increase of 17-OH-progesterone by 2.2 times (p = 0.0005), and dehydroepiandrosterone sulfate by 1.3 times (p = 0.0001). A decrease in the total antioxidant activity of the blood by 25 % (p = 0.0005), an increase in the content of oxidized glutathione by 14 % (p = 0.0001) and a decrease in the concentration of retinol by 26 % (p = 0.0012) compared to the control values were shown. The increase in the degree of oxidative stress was indicated by the value of the coefficient of oxidative stress equal to 2.8. Conclusion. The obtained data indicate the features of the functional state of the pituitary-ovarian-adrenal system and the processes of LPO–AOP, as well as the need for timely diagnosis and effective correction of hormonal and metabolic disorders in women with polycystic ovary syndrome in the early reproductive period.