Abstract
Analysis of knockout mice has brought into question the previously proposed role of the phosphatidylserine receptor (Ptdsr) in the clearance of apoptotic cell corpses, and has suggested important functions in regulating differentiation and inflammation.
Highlights
Analysis of knockout mice has brought into question the previously proposed role of the phosphatidylserine receptor (Ptdsr) in the clearance of apoptotic cell corpses, and has suggested important functions in regulating differentiation and inflammation
In Journal of Biology [2], Andreas Lengeling and colleagues reveal more surprises about the phosphatidylserine receptor (Ptdsr) molecule that was first cloned as a receptor responsible for the phosphatidylserine-specific clearance of apoptotic cells
Phage display can be used to screen a library of recombinant peptides expressed on the surface of bacteriophages, and was used to identify the antigen recognized by a phagocytosis-inhibiting monoclonal antibody mAb 217 during the cloning of the phosphatidylserine receptor Ptdsr
Summary
Analysis of knockout mice has brought into question the previously proposed role of the phosphatidylserine receptor (Ptdsr) in the clearance of apoptotic cell corpses, and has suggested important functions in regulating differentiation and inflammation. “Curiouser and curiouser!” cried Alice when she realized the startling effects of ingesting a small cake on which the words ‘Eat me’ were beautifully marked in currants [1]. Dying cells display enticing ‘eat me’ signals and a collection of colorful molecular characters to ensure their digestion. In Journal of Biology [2], Andreas Lengeling and colleagues reveal more surprises about the phosphatidylserine receptor (Ptdsr) molecule that was first cloned as a receptor responsible for the phosphatidylserine-specific clearance of apoptotic cells (see ‘The bottom line’ box for a summary of the work)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
