Abstract
The ability of CRISPR/Cas9 plasmids encoding various HSV-1 genes to inhibit HSV-1 infection in vitro was studied. It was shown that CRISPR/Cas9 plasmids encoding two gRNA targeted against UL52 and UL29 genes of the HSV1 primase-helicase complex suppressed the viral reproduction in a Vero cell culture completely.
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