Abstract
BackgroundThe coupling of pathways and processes through shared components is being increasingly recognised as a common theme which occurs in many cell signalling contexts, in which it plays highly non-trivial roles.ResultsIn this paper we develop a basic modelling and systems framework in a general setting for understanding the coupling of processes and pathways through shared components. Our modelling framework starts with the interaction of two components with a common third component and includes production and degradation of all these components. We analyze the signal processing in our model to elucidate different aspects of the coupling. We show how different kinds of responses, including "ultrasensitive" and adaptive responses, may occur in this setting. We then build on the basic model structure and examine the effects of additional control regulation, switch-like signal processing, and spatial signalling. In the process, we identify a way in which allosteric regulation may contribute to signalling specificity, and how competitive effects may allow an enzyme to robustly coordinate and time the activation of parallel pathways.ConclusionsWe have developed and analyzed a common systems platform for examining the effects of coupling of processes through shared components. This can be the basis for subsequent expansion and understanding the many biologically observed variations on this common theme.
Highlights
The coupling of pathways and processes through shared components is being increasingly recognised as a common theme which occurs in many cell signalling contexts, in which it plays highly non-trivial roles
The results are organized as follows: we use our modelling framework to study how the system responds to different signals from both steady state and temporal perspectives
Modulation of the shared component We begin by analysing the steady state response of the system to changes in the production of X
Summary
The coupling of pathways and processes through shared components is being increasingly recognised as a common theme which occurs in many cell signalling contexts, in which it plays highly non-trivial roles. In order to do this, their components often interact with multiple entities at multiple locations, allowing them to receive and send multiple signals. This property is seen, for example, in proteins capable of multiple allosteric interactions such as n-WASP [1], WAVE [2], Cdk-2 [3], and PLC [4]. Substrates may be modified by multiple enzymes, as is the case for the p53 tumour suppressor [13] and many GTPases Each of these reactions may take place while bound to various adaptor and scaffold structures, as is common for
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