The correlations among cervical cancer, human papilloma virus infection and soluble tumor necrosis factor receptors

Abstract

Objective To explore the relationship between cervical cancer and human papilloma virus(HPV) infection as well as soluble tumor necrosis factor receptors (STNFR).Methods A total of 53 patients with cervical cancer were enrolled in the case group,while 50 healthy subjects were included in the control group.Clinical data,HPV and STNFR testing results of two groups were collected,analyzed and compared.Results 62.26％ and 16.00％ subjects in case group and control group respectively got infected with HPV.There was significant difference between the infection rate(P ＜ 0.01).The level of STNFR Ⅰ and STNFR Ⅱ were 1842.65 ± 1124.35pg· ml-1 and 3248.60 ± 1048.65pg· ml-1 respectively in case group,which were significantly higher than that of control group (849.32 ± 228.74pg· ml-1 and 1653.27 ± 358.42pg· ml-1) (STNFRⅠ: P =0.043,STNFR Ⅱ: P =0.047).In the case group,the level of STNFR Ⅰ (2210.52 ± 1213.71pg· ml-1) and STNFR Ⅱ (3679.24 ± 1088.15pg· ml-1) in subjects with HPV infection were significantly higher than that of patients without HPV infection (STNFR Ⅰ: 1149.34 ± 603.14 pg· ml-1,STNFR Ⅱ2667.23 ± 819.87pg· ml-1) before surgery.However,after surgery,there were no statistically differences between the level of STNFR Ⅰ and STNFRⅡamong patients with or without HPV infection.In case group,the level of STNFR Ⅰ(1080.31 ±249.67pg· ml-1) and STNFRⅡ(1896.32 ±211.75pg· ml-1) after surgery were statistically lower than that before surgery(STNFR Ⅰ: 1822.36 ± 1128.16pg· ml-1,STNFR Ⅱ: 3293.14 ± 1021.58pg· ml-1) (STNFRⅠ: P =0.039,STNFRⅡ: P =0.006).Conclusions Cervical cancer were associated HPV infection and the level of STNFR Ⅰ and STNFRⅡ. Key words: Cervical cancer; Human papilloma virus; Soluble tumor necrosis factor receptors