The correlation study between behavioral and genetic factors and type 2 diabetes mellitus

Abstract

Objective To study the relationship between behavioral,genetic factors and type 2 diabetes mellitus,and provide rational evidence for prevention and intervention of type 2 diabetes mellitus.Methods Case control study is adopted in the research,152 cases with type 2 diabetes mellitus and 120 controls were brought into the study,collecting information of their life styles and behavior,tracing information of their first degree relatives;single and multi-factor logistic regression are applied to analyze the effect of the studying factors on type 2 diabetes mellitus.Falconer formula is adopted to estimate heritability.Results According to multi-factor logistic regression,the factors associated with type 2 diabetes mellitus include:the family history of diabetes mellitus,absorbing too much fat,enjoying sweetmeats,take exercises,eating green flesh vegetables and waist haunch ratio(WHR)et al.The cumulative incidence rate of first degree relatives in eases is 7.55%,which is higher than that of controls (0.73%),the difference between the two is distinctly(x2=66.07,P＜0.01).By Falconer formula,the heritabilitv of type 2 diabetes mellitus is 72.2%.which indicate that heredity account for a big proportion in the occurrence of type 2 diabetes mellitus.Conclusion Type 2 diabetes mellitus is caused by the combining effects of genetic and behavior risky factors. Key words: Behavior ; Genetic factors ; Type 2 diabetes mellitus ;