Abstract
IntroductionThe relationship between clinical prognostic factors and blood neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in some tumors has been investigated. In this study, we examined whether there is a relationship between pathological prognostic factors and NLR as well as PLR only in neuroendocrine tumors (NETs).MethodsA total of 115 patients with a NET diagnosis between 2014-2020 were included in the study. The efficiency of NLR and PLR in predicting distant metastases was determined by analyzing the receiver operating characteristic (ROC) curve. The relationship between histopathological parameters was also compared.ResultsThe cut-off value of NLR was 3.01 for predicting distant metastasis. At this value, the specificity was 73.7%, the sensitivity was 70.7%, and the likelihood ratio was 2.51. There was a significant relationship between NLR and tumor localization, histological grade, mitosis, Ki-67, distant metastasis, and lymphovascular invasion (all p<0.001). The cut-off value of the PLR in predicting distant metastasis was 134.4. At this value, the specificity was 59.6%, the sensitivity was 58.6%, and the likelihood ratio was 1.44. There was no significant relationship between PLR and the histopathological findings (all p>0.05).ConclusionsIn our study, a high histological grade, high mitosis, a high Ki-67 proliferation index, distant metastasis, and lymphovascular invasion were found in patients with NLR at a cut-off value above 3.01. However, we could not attain the same results for PLR. For trucut and endoscopic biopsies in particular, follow-up of patients with grades 1 and 2 NETs along with histopathological findings and evaluation of NLR in peripheral blood may be useful. NLR, which is an easily accessible inflammatory marker, can be used as an independent predictive factor in NETs.
Highlights
The relationship between clinical prognostic factors and blood neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in some tumors has been investigated
A high histological grade, high mitosis, a high Ki-67 proliferation index, distant metastasis, and lymphovascular invasion were found in patients with NLR at a cut-off value above 3.01
It is thought that a systemic inflammatory response is associated with poor prognosis in many cancers in terms of predicting tumor invasion, metastasis, and angiogenesis [3]
Summary
A total of 115 patients with a NET diagnosis between 2014-2020 were included in the study. The efficiency of NLR and PLR in predicting distant metastases was determined by analyzing the receiver operating characteristic (ROC) curve. Patients who were diagnosed with NET via tru-cut biopsy, endoscopic biopsy, colonoscopic biopsy, excisional biopsy, or resection materials were re-evaluated by an experienced pathologist. For cases of NETs with metastases on imaging, those with a diagnosis of metastasis that was confirmed by biopsy or tumor resection were included in the study. Patients who were not diagnosed with a biopsy, those who had a recurrent tumor and received chemoradiotherapy were excluded from the study. Gender, tumor localization, histological grade, mitosis, distant metastasis, lymphovascular invasion, perineural invasion, immunohistochemical Ki-67, synaptophysin and chromogranin A staining, and a correlation between NLR and PLR in peripheral blood were evaluated in all patients. Tumor localizations were grouped into those in the gastroenteropancreatic system (esophagus, stomach, small intestine, large intestine, appendix, pancreas), lungs, and other organs
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
