The correlation of intra-abdominal fat area with insulin resistance in male with abdominal obesity

Abstract

Objective To investigate the relationship between intra-abdominal fat area（IAFA）in male with abdominal obesity and glycometabolism related indicators. Methods Ninety-four obesity males,aged from 21 to 62 years old,were selected as our subjects. They were divided into abdominal obesity group（n = 70）and non-abdominal obesity group（ n = 24）. The general information of all subjects was recorded. The indexes of height,weight,waist circumference,hip circumference,body mass index（BMI）were measured. The fasting oral glucose tolerance test was performed. The levels of blood glucose（0,1,2 h）and insulin（0,1,2 h）were measured,and insulin resistance index was calculated. MRI measurement was applied to calculate the IAFA. Compared the difference between the two groups in term of the level of blood glucose,insulin and insulin resistance index,and analyzed the correlation between glycometabolism related indicators and IAFA. Results BMI,waist circumference,hip circumference,insulin resistance index and IAFA in abdominal obesity group were （28. 67 ± 4. 20）kg/ m2 ,（99. 75 ± 4. 07）cm,（104. 42 ± 7. 62）cm,2. 60 ± 1. 80,（153. 06 ± 53. 23）cm2 respectively,higher than those in non-abdominal obesity group（（21. 80 ± 1. 97）kg/ m2 ,（79. 50 ± 10. 05）cm, （91. 86 ± 4. 49）cm,1. 52 ± 0. 73,（71. 78 ± 25. 48）cm2 ）,and the differences were statistically significant（t= - 7. 704,- 9. 583,- 7. 618,- 2. 877,- 7. 184,P 〈 0. 05）. The level of blood glucose at 0,1,2 h of patient in abdominal obesity group were（5. 89 ± 1. 36）mmol/ L,（10. 55 ± 3. 07）mmol/ L,and（8. 41 ± 3. 63） mmol/ L,higher than that in non-abdominal obesity group（（5. 29 ± 0. 53）mmol/ L,（8. 76 ± 1. 96）mmol/ L, （6. 54 ± 1. 50）mmol/ L）. Meanwhile,The insulin at 0,1,2 h of man in abdominal obesity group were（9. 71 ± 5. 05）mU/ L,（83. 29 ± 64. 51）mU/ L,（63. 56 ± 21. 09）mU/ L）,significantly higher than those in non-abdominal obesity group（（6. 42 ± 2. 96）mU/ L,（33. 00 ± 19. 82）mU/ L,（63. 56 ± 21. 09）mU/ L）,and the differences were significant（ t = - 2. 098,- 2. 671;- 2. 447,- 3. 010;- 3. 784,- 3. 089;P 〈 0. 05）. The IAFA in abdominal obesity was positively correlated with age,BMI,waist circumference,hip circumference,blood glucose（0,1,2 h）insulin（0,2 h）and insulin resistance index（r = 0. 254,0. 533,0. 521,0. 615,0. 245,0. 315, 0. 294,0273,0. 249,0. 225,P 〈 0. 05 ）. After adjustment for confounding factors,age（ x1 ）,abdominal circumference（x2）and insulin resistance index（x3）were related to IAFA（y = 1. 369x1 ＋ 4. 472x2 ＋ 25. 072x3- 333. 626）. Conclusion Compared with patients with non-abdominal obesity,the IAFA of patient with abdominal obesity with abdominal fat area size is associated with insulin resistance. Key words: Abdominal obesity; Abdominal fat area; Insulin resistance; Glucose metabolism