Abstract
Objective To evaluate the relationship between fat distribution and carotid intima-media thickness (CIMT) in young and middle-aged men.Methods Five hundred and one men aged 20-50 years who took physical examination in the first hospital of qinhuangdao were selected.The abdominal obesity group included 299 cases with waist circumference ≥90 cm,and the normol waist circumference group included 202 cases with waist circumference ＜90 cm.Height,weight and waist circumference were measured and body mass index was calculated.Fasting insulin (FINS) and fasting plasma glucose (FPG) were detected,and homeostasis model assay insulin resistance index (HOMA-IR) was calculated.Total body fat mass (BF),body muscle mass (BM),truncal fat mass (TrF),upper limb fat mass (UF),limb fat mass (LF) were measured by dual energy X-ray absorptiometry (DEXA).BF％(＝BF/W) and TrF/BF were calculated.CIMT was detected with color ultrasound.Results (1) The abdominal obesity group showed increased levels of BF％,TrF/BF,BF,BM,TrF,UF,LF,body mass index,waist circumference,CIMT and HOMA-IR,compared with normol waist circumference group (all P ＜0.05).(2) In Pearson correlation analysis,CIMT had positive correlation with BF％,TrF/BF,BF,BM,TrF,UF,LF,body mass index and waist circumference (R＝0.443,0.481,0.429,0.377,0.472,0.376,0.304,all P ＜0.05).(3)In Pearson correlation analysis,HOMA-IR had positive correlation with BF％,TrF/BF,BF,BM,TrF,UF,LF,body mass index,waist circumference(R =0.510,0.441,0.576,0.502,0.528,0.526,0.577,0.384,0.639,all P＜0.05).HOMA-IR had positive correlation with CIMT (R =0.416,P ＜0.05).(4)In multiple regression analyses,TrF/BF and body mass index were the independent risk factors of CIMT.Conclusion Fat distribution was closely related with CIMT and insulin resistance in young and middle-aged men.To prevent carotid atherosclerosis and cardiovascular diseases,exercise should be recommended and abdominal obesity should be avoided. Key words: Abdominal obesity; Fat distribution; Carotid intima-media thickness; Young and middle-aged men
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