The correlation between vaginal intraepithelial neoplasia and cervical intraepithelial neoplasia, and their risk factors

Abstract

Objective To investigate the correlation and risk factors between vaginal intraepithelial neoplasia (VAIN) and cervical intraepithelial neoplasia (CIN). Methods A total of 121 cases of VAIN patients was retrospectively analyzed with examination results such as clinical manifestations, liquid based cytology (TCT), human papilloma virus infection, virus infection type, and clinical data of treatment and follow up. Results VAIN Ⅰ, VAIN Ⅱ, and VAIN Ⅲ were accounted for 33.9%(41/121), 38.0% (46/121), and 24.4% (34/121); for 40 or less years old patients, VAIN Ⅲ was accounted for 10.7% (3/28); for more than 40 years old patients, VAIN Ⅲ was accounted for 33.3% (31 /93) . Among 121 VAIN patients, 77.7% (94/121) patients had CIN history, 15.7% of which (19/121) had a history of cervical cancer; 27.3% (33/121) with hysterectomy history, of which 75.8% (25/33) was due to cervical intraepithelial neoplasia and cervical cancer resection of the uterus. Papilloma viral load in patients with VAIN Ⅰ was detected with a (HPV-HC2) positive rate of 87.8% (36/41), while in VAIN Ⅱ and VAIN Ⅲ patients, the positive rate was 100%, the infection of high risk type of HPV ratio was 95.9% (116/121), of which the mixed infection was accounted for 56.9% (66/116). There was 94.6% in patients with VAIN (114/121), and liquid-based cytology test results suggest abnormality; 88.4% (107/121) in patients with VAIN lesions occurred in upper 1/3 of vaginal. After diagnosed cervical disease, the onset time of VAIN was (3.45±2.02) years, non-total-hysterectomy was (3.24±1.97) years, after hysterectomy to pathological diagnosis time for VAIN was (5.01±3.95) years: for the diagnosis of VAIN disease after resection of cervical original time was (3.96±2.99) years, and rather than non cervical disease resection was an average of (9.94±5.37) years. In the course of treatment of the 121 cases of CIN patients, 6 cases of patients were progressed to invasive carcinoma. Conclusions The clinical manifestation of VAIN is similar to CIN, the principle of diagnosis and treatment of CIN can also apply to VAIN, high risk HPV infection virus, cervical intraepithelial neoplasia are the risk factors for VAIN. Key words: Vaginal neoplasms; Cervical intraepithelial neoplasia; Risk factors; Retrospective studies