Abstract
Objective: The examination of nesfatin-1 level in females with gestational diabetes versus controls and itsrelation with the markers of insulin resistance.Method: The study was accomplished for eighty eight pregnant females at 24th -28th week of gestationwhich were involved 44 females diagnosed with gestational diabetes and 44 females without. Age andbone mass index were matched in two groups. Nesfatin-1 and insulin concentrations were measured byusing enzyme linked immunosorbent assay. Insulin level and (homeostasis model assessment index- insulinresistance) were measured in two groups. The manufacture instructions were performed accurately. Thecomparison between previous parameters was performed.Results: The level of nesfatin-1 wasn´t differed significantly between two groups. While insulin, homeostasismodel assessment index-insulin resistance and fasting blood glucose were significantly increased ingestational diabetes than control groups.Conclusion: The mean of nesfatin-1 levels showed no significant difference between two groups. Whilefasting blood glucose, insulin, and homeostasis model assessment index-insulin resistance were significantlyhigher in GDM. Advance age, higher bone mass index were associated of gestational diabetes.
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