Abstract
Introduction. Evaluation of the first trimester uterine artery flow can predict the development of obstetrical complications. A genotype, making women prone to microthrombi. constitutes the main known susceptibility factor for anomalous development of placenta. Our aim was to study whether polymorphisms of 10 genes leading to blood clotting abnormalities are related to abnormal uterine artery blood flow in the first trimester, and may predict placenta-related diseases. Material and methods. In primary analyses we included 19 singleton pregnancies with abnormal blood flow in the uterine arteries during the first trimester of gestation, and 24 matched control with normal flow patterns. All patients were genotyped for sequence variations in F5, F2, F11, MTHFR, SERPINE-1, CYP4V2, SELE, GP6, angiotensinogen (AGT) and fibrinogen gamma (FGG) genes and followed up until delivery. Results. There were no differences between groups regarding selected sequence variations in any of these genes. The co-occurrence of several polymorphisms in the same patient was also not related to the blood flow patterns in the uterine arteries. Conclusions. Although we found certain trends of genetic polymorphisms being related to preeclampsia and fetal growth, we failed to find an association between clotting gene polymorphisms, single or in combination, with the abnormal uterine flow in the first trimester.
Highlights
Evaluation of the first trimester uterine artery flow can predict the development of obstetrical complications
Our aim is to study whether genetic polymorphisms causing thrombophilic predisposition are related to abnormal uterine artery blood flow in the first trimester of pregnancy, which reflects abnormal trophoblast invasion
In the present work we studied the hypothesis that genetic polymorphisms can contribute to uterine blood flow changes in order to better understand one of the most mysterious diseases in obstetrics
Summary
Evaluation of the first trimester uterine artery flow can predict the development of obstetrical complications. Our aim was to study whether polymorphisms of 10 genes leading to blood clotting abnormalities are related to abnormal uterine artery blood flow in the first trimester, and may predict placenta-related diseases. In 2017, PE/E was diagnosed in 400 (2.0%) and hypertension during pregnancy in 707 (3.4%) of 20,406 births in Latvia, (www.spkc.gov.lv). In the period 2013–2015, maternal mortality due to PE/E was as high as 1.6 per 100,000 live births in Latvia, compared to only 0.08 in the UK (period 2009–2014) [2]. Following Mendelian patterns of disease inheritance, many families have “private” genes predisposing them to micro-thrombi leading to abnormal placental circulation. Mutations in SERPINC1, the gene encoding antithrombin, are associated with pathogenicity during gestation under specific conditions [4]
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