The correlated study of peptic ulcer combined with bleeding caused by Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs

Abstract

Objective To research the relationship between Helicobacter pylori infection,nonsteroidal anti-inflammatory drugs (NSAIDs) and peptic ulcer combined with bleeding.Methods The clinical data of 180 peptic ulcer patients from January 2012 to June 2013 were analyzed retrospectively,and they were divided into bleeding group (75 patients) and non-bleeding group (105 patients).The risk factors of bleeding were analyzed.Results The single factor analysis showed that age ≥60 years,history of alimentary tract hemorrhage,cardiovascular and cerebrovascular diseases,and simple caplendused NSAIDs were the risk factors of peptic ulcer combined with bleeding (P ＜ 0.01).Multiple factors Logistic regression analysis showed that age ≥60 years [OR(95％ CI):0.9(0.5-1.7),P=0.003],history of peptic ulcer [OR (95％ CI):1.4 (0.7-2.6),P =0.006],history of alimentary tract hemorrhage [OR (95％ CI):2.1 (1.4-3.0),P=0.007],single Helicobacter pylori infection [OR (95％ CI):3.2(2.1-4.2),P=0.001],history of cardiovascular and cerebrovascular diseases [OR (95％ CI):1.3 (0.5-1.9),P =0.005],simple caplendused NSAIDs [OR (95％ CI):2.4 (1.6-3.5),P =0.001] were independent risk factors of peptic ulcer combined with bleeding.Helicobacter pylori infection combined with NSAIDs could improve the incidence rate of peptic ulcer combined with bleeding(P ＜ 0.01).Conclusion Helicobacter pylori infection combined with NSAIDs can improve the incidence rate and risk of peptic ulcer combined with bleeding. Key words: Helicobacter pylori; Peptic ulcer; Non-steroidal anti-inflammatory drugs