Effect of helicobacter pylori infection on nonsteroidal anti-inflammatory drugs related peptic ulcer

Abstract

Objective To investigate the effect of helicobacter pylori(HP) infection on peptic ulcer associated with nonsteroidal anti-inflammatory drugs(NSAID). Methods A total of 275 patients who consulted in hospital and required to take NSAID for long-term(>3 months) all underwent 13carbon urea breath test(13C-UBT )before taking NSAID. A total of 165 patients whose results of 13C-UBT showed positive all done gastroscopy, and the gastroscopy results showed 132 patients had no disorders of stomath and duodenum. The 132 patients were randomly divided into two groups: eradicating HP group (group 1) and non eradicating HP group(group 2), with 66 cases in each group. The 66 patients in each group were divided into high risk group and non high risk group according to risk factors of peptic ulcer associated with NSAID. Group 1 received tripe anti-HP therapy for 2 weeks before orally taking NISAID, and reexamined 13C-UBT after 1 month. The patients whose results of 13C-UBT showed negative and group 2 took NSAID for 3 months and redone gastroscopy. The number of patients who had peptic ulcer was figured out according to the gastroscopy. Results Sixty-six patients in group 1 were reexamined with 13C-UBT of which 2 patients still presented negative results and were removed. The incidence of peptic ulcer was 28.6%(16/64) in group 1 and 48.5%(31/66) in group 2, there was a signifinant difference between the two groups(P<0.05). The incidence of peptic ulcer was 35.5% in high risk group of group 1 and 48.5% in high risk group of group 2, there was a signifinant difference between the two groups(P<0.05). Conclusions For the patients required to take NSAID for long-term(>3 months), espicially for the high risk group, receive tripe anti-HP therapy before take NSAID can signifinantly reduce the incidence of peptic ulcer. Key words: Helicobacter pylori; Nonsteroidal anti-inflammatory drugs; Peptic ulcer